Key Articles — The Chun Lab

Fingolimod: Direct CNS Effects of Sphingosine 1- Phosphate (S1P) Receptor Modulation and Implications in Multiple Sclerosis Therapy

Groves A, Kihara Y, Chun J. J Neurol Sci 2013;328(1-2):9-18.

Type: Review, Year: 2013, Publications, Highlighted ArticlesScienceSitesSeptember 30, 2021S1P and MS

A Functionally Defined in Vivo Astrocyte Population Identified By c-Fos Activation in a Mouse Model of Multiple Sclerosis Modulated by S1P Signaling: Immediate Early Astrocytes (ieAstrocytes)

Groves A, Kihara Y, Jonnalagadda D, Rivera R, Kennedy G, Mayford M, Chun J. eNeuro 2018; 5(5).

Type: Article, Year: 2018, Publications, Highlighted ArticlesScienceSitesSeptember 30, 2021S1P and MS

FTY720 (Fingolimod) Efficacy in an Animal Model of Multiple Sclerosis Requires Astrocyte Sphingosine 1-Phosphate Receptor (S1P1) Modulation

Choi JW, Gardell SE, Herr DR, Rivera R, Lee CW, Noguchi K, Teo ST, Yung YC, Lu M, Kennedy G, Chun J. Proc Natl Acad Sci USA 2011;108(2):751-756.

Type: Article, Year: 2011, Publications, Highlighted ArticlesScienceSitesSeptember 30, 2021S1P and MS

Fingolimod: Lessons Learned and New Opportunities for Treating Multiple Sclerosis and Other Disorders

Chun J, Kihara Y, Jonnalagadda D, Blaho VA. Annu Rev Pharmacol Toxicol 2019;59:149-170.

Type: Review, Year: 2019, Publications, Highlighted ArticlesScienceSitesSeptember 30, 2021S1P and MS

Lysophosphatidic Acid Signaling in the Nervous System

Yung YC, Stoddard NC, Mirendil H, Chun J. Neuron 2015;85(4):669-682. doi:10.1016/j.neuron.2015.01.009.

Type: Review, Year: 2015, Publications, Highlighted ArticlesScienceSitesSeptember 30, 2021LRS Intro, LPA and Hydrocephalus

LPA Receptors: Subtypes and Biological Actions

Choi JW, Herr DR, Noguchi K, Yung YC, Lee CW, Mutoh T, Lin M-E, Teo ST, Park KE, Mosley AN, Chun J. Ann Rev Pharmacol Toxicol 2010;50:157–186.

Type: Review, Year: 2010, Publications, Highlighted ArticlesScienceSitesSeptember 30, 2021LRS Intro

Non-Proliferative Effects of Lysophosphatidic Acid Enhance Cortical Growth and Folding

Kingsbury MA, Rehen SK, Contos JJA, Higgins C, Chun J. Nature Neurosci 2003;6:1292- 1299.

Type: Article, Year: 2003, Publications, Highlighted ArticlesScienceSitesSeptember 30, 2021LRS Intro

Ventricular Zone Gene -1 (Vzg-1) Encodes a Lysophosphatidic Acid Receptor Expressed in Neurogenic Regions of the Developing Cerebral Cortex

Hecht JH, Weiner JA, Post SR, Chun J. J Cell Biol 1996;135:1071-1083.

Type: Article, Year: 1996, Publications, Highlighted ArticlesScienceSitesSeptember 30, 2021LRS Intro

Requirement for the lpA1 Lysophosphatidic Acid Receptor Gene in Normal Suckling Behavior

Contos JJA, Fukushima N, Weiner JA, Kaushal D, Chun J. Proc Natl Acad Sci USA 2000;97:13384-13389.

Type: Article, Year: 2000, Publications, Highlighted ArticlesScienceSitesSeptember 30, 2021LRS Intro

Crystal Structure of Antagonist Bound Human Lysophosphatidic Acid Receptor 1

Chrencik JE, Roth CB, Terakado M, Kurata H, Omi R, Kihara Y, Warshaviak D, Nakade S, Asmar-Rovira G, Mileni M, Mizuno H, Griffith MT, Rodgers C, Han GW, Velasquez J, Chun J*, Stevens RC*, Hanson MA*. Cell 2015;161:1633-1643.
*co-senior authors.

Type: Article, Year: 2015, Publications, Highlighted ArticlesScienceSitesSeptember 30, 2021LRS Intro

Aneuploid Cells Are Differentially Susceptible to Caspase-Mediated Death During Embryonic Cerebral Cortical Development

Peterson SE, Yang AH, Bushman DM, Westra JW, Yung YC, Barral S, Mutoh T, Rehen SK, Chun J. J Neurosci 2012;32(46):16213-16222.

Type: Article, Year: 2012, Publications, Highlighted ArticlesScienceSitesSeptember 30, 2021Other Forms of SGM

Constitutional Aneuploidy in the Normal Human Brain

Rehen SK, Yung YC, McCreight MP, Yang AH, Almeida BSV, Kingsbury MA, Cabral KMS, Kaushal D, McConnell MJ, Anliker B, Fontanoz M, Chun J. J Neurosci 2005;25:2176-2180.

Type: Article, Year: 2005, Publications, Highlighted ArticlesScienceSitesSeptember 30, 2021Other Forms of SGM

Chromosomal Variation in Neurons of the Developing and Adult Mammalian Nervous System

Rehen SK, McConnell MJ, Kaushal D, Kingsbury MA, Yang AH, Chun J. Proc Natl Acad Sci USA, 2001;98:13361-13366.

Type: Article, Year: 2001, Publications, Highlighted ArticlesScienceSitesSeptember 30, 2021Other Forms of SGM

Submegabase Copy Number Variations Arise During Cerebral Cortical Neurogenesis as Revealed By Single-Cell Whole-Genome Sequencing

Rohrback S, April C, Kaper F, Rivera RR, Liu CS, Siddoway B, Chun J. Proc Natl Acad Sci USA 2018;115(42):10804-10809.

Type: Article, Year: 2018, Publications, Highlighted ArticlesScienceSitesSeptember 30, 2021Other Forms of SGM

Neuronal DNA Content Variation (DCV) With Regional and Individual Differences in the Human Brain

Westra JW, Rivera RR, Bushman DM, Yung YC, Peterson SE, Barral S, Chun J. J Comp Neuro 2010;518(19):3981-4000.