Key Articles — The Chun Lab

RNA isoform diversity in human neurodegenerative diseases

Liu CS, Park C, Ngo T, Saikumar J, Palmer CR, Shahnaee A, Romanow WJ, Chun J. eNeuro. 2024

Type: Article, Publications, Highlighted Articles, Year: 2024ScienceSitesDecember 10, 2024SCT, AD and ADRDS

Human brain small extracellular vesicles contain selectively packaged, full-length mRNA

Ransom LS, Liu CS, Dunsmore E, Palmer CR, Nicodemus J, Ziomek D, Williams N, Chun J. Cell Reports. 2024.

Type: Article, Publications, Highlighted Articles, Year: 2024ScienceSitesApril 5, 2024SGR

FTY720 requires vitamin B(12)-TCN2-CD320 signaling in astrocytes to reduce disease in an animal model of multiple sclerosis

Jonnalagadda D, Kihara Y, Groves A, Ray M, Saha A, Ellington C, Lee-Okada HC, Furihata T, Yokomizo T, Quadros EV, Rivera R, Chun J. Cell Reports. 2023

Type: Article, Publications, Highlighted Articles, Year: 2023ScienceSitesDecember 8, 2023S1P and MS

Single-Nucleus RNA-seq of Normal-Appearing Brain Regions in Relapsing-Remitting vs. Secondary Progressive Multiple Sclerosis: Implications for the Efficacy of Fingolimod

Kihara Y, Zhu Y, Jonnalagadda D, Romanow W, Palmer C, Siddoway B, Rivera R, Dutta R, Trapp BD, Chun J.. Frontiers in Cellular Neuroscience. 2022.

Type: Article, Year: 2018, Publications, Highlighted ArticlesScienceSitesSeptember 30, 2022SCT, S1P and MS

Ponesimod inhibits astrocyte-mediated neuroinflammation and protects against cingulum demyelination via S1P(1) -selective modulation

Kihara Y, Jonnalagadda D, Zhu Y, Ray M, Ngo T, Palmer C, Rivera R, Chun J. FASEB Journal 2022.

Gwen KaeserJanuary 5, 2022S1P and MS

S1P(2)-Gα(12) Signaling Controls Astrocytic Glutamate Uptake and Mitochondrial Oxygen Consumption

Jonnalagadda D, Kihara Y, Rivera R, Chun J. eNeuro 2021.

Highlighted Articles, Publications, Type: Article, Year: 2021Gwen KaeserDecember 3, 2021S1P and MS

Altered cell and RNA isoform diversity in aging Down syndrome brains

Palmer CR, Liu CS, Romanow WJ, Lee MH, Chun J. PNAS 2021.

Highlighted Articles, Publications, Type: Article, Year: 2021Gwen KaeserDecember 3, 2021SCT

Characterizing Transcriptional Heterogeneity Through Pathway and Gene Set Overdispersion Analysis

Fan J, Salathia N, Liu R, Kaeser GE, Yung YC, Herman JL, Kaper F, Fan JB, Zhang K, Chun J, Kharchenko PV. Nat Methods 2016;13(3):241-244.

Type: Article, Year: 2016, Publications, Highlighted ArticlesScienceSitesSeptember 30, 2021SCT

Neuronal Subtypes and Diversity Revealed By Single-Nucleus RNA Sequencing of the Human Brain

Lake BB, Ai R, Kaeser GE, Salathia NS, Yung YC, Liu R, Wildberg A, Gao D, Fung H-L, Chen S, Vijayaraghavan R, Wong J, Chen C, Sheng X, Kaper F, Shen R, Ronaghi M, Fan J-B, *Wang W, *Chun J, *Zhang K. Science 2016;352(6293):1586-1590.
*co-senior authors

Type: Article, Year: 2016, Publications, Highlighted ArticlesScienceSitesSeptember 30, 2021SCT

A Comparative Strategy for Single-Nucleus and Single-Cell Transcriptomes Confirms Accuracy in Predicted Cell-Type Expression From Nuclear RNA

Lake BB, Codeluppi S, Yung YC, Chun J, Kharchenko PV, Linnarsson S, Zhang K. Sci Rep 2017;7(1):6031.

Type: Article, Year: 2017, Publications, Highlighted ArticlesScienceSitesSeptember 30, 2021SCT

Integrative Single-Cell Analysis of Transcriptional and Epigenetic States in the Human Adult Brain

Lake BB, Chen S, Sos BC, Fan J, Kaeser GE, Yung YC, Duong TE, Gao D, Chun J, Kharchenko PV, Zhang K. Nat Biotechnol 2018;36(1):70-80.

Type: Article, Year: 2018, Publications, Highlighted ArticlesScienceSitesSeptember 30, 2021SCT

Unlabeled Lysophosphatidic Acid Receptor Binding in Free Solution as Determined By a Compensated Interferometric Reader

Ray M, Nagai K, Kihara Y, Kussrow A, Kammer MN, Frantz A, Bornhop DJ, Chun J. J Lipid Res J Lipid Res 2020;61(8):1244-1251.