Highlighted Articles — Publications

McDonald WS, Miyamoto K, Rivera R, Kennedy G, Almeida BSV , Kingsbury MA, and Chun J. Molecular Brain 2020;13(1):169. doi: 10.1186/s13041-020-00709-y.

Reply: Evidence That APP Gene Copy Number Changes Reflect Recombinant Vector Contamination

Lee MH, Liu CS, Zhu Y, Kaeser GE, Rivera R, Romanow WJ, Kihara Y, Chun J. Nature 2020;584(7821):E29-E33. doi:10.1038/s41586-020-2523-2.

Conditional Lpar1 Gene Targeting Identifies Cell Types Mediating Neuropathic Pain

Rivera RR, Lin ME, Bornhop EC, Chun J. FASEB J 2020;34:8833-8842.

Type: Article, Year: 2020, Publications, Highlighted ArticlesScienceSitesJune 7, 2021LPA

Unlabeled Lysophosphatidic Acid Receptor Binding in Free Solution as Determined By a Compensated Interferometric Reader

Ray M, Nagai K, Kihara Y, Kussrow A, Kammer MN, Frantz A, Bornhop DJ, Chun J. Journal of Lipid Research. 2020.

Brain Cell Somatic Gene Recombination and Its Phylogenetic Foundations

Kaeser GE, Chun J. J Biol Chem 2020;295(36):12786-12795.

Mosaic Somatic Gene Recombination as a Potentially Unifying Hypothesis for Alzheimer’s Disease

Kaeser GE, Chun J. Front Genet 2020;11:390. doi: 10.3389/fgene.2020.00390.

LPA1/3 Overactivation Induces Neonatal Post-Hemorrhagic Hydrocephalus Through Ependymal Loss and Ciliary Dysfunction

Lummis NC, Sanchez-Pavon P, Kennedy G, Frantz AJ, Kihara Y, Blaho VA, Chun J. Sci Advances 2019;5(10):eaax2011.

Type: Article, Year: 2019, Publications, Highlighted ArticlesScienceSitesJune 7, 2021Hydrocephalus, LPA

Mosaic APP Gene Recombination in Alzheimer’s Disease - What’s Next?

Lee MH, Chun J. J Exp Neurosci 2019;13. doi:10.1177/1179069519849669.

Lysophospholipid G Protein-Coupled Receptor Binding Parameters as Determined By Backscattering Interferometry

Mizuno H, Kihara Y, Kussrow A, Chen A, Ray M, Rivera R, Bornhop D, Chun J. J Lipid Res 2019;60(1):212-217.

Fingolimod: Lessons Learned and New Opportunities for Treating Multiple Sclerosis and Other Disorders

Chun J, Kihara Y, Jonnalagadda D, Blaho VA. Annu Rev Pharmacol Toxicol 2019;59:149-170.

Somatic APP Gene Recombination in Alzheimer’s Disease and Normal Neurons

Lee MH, Siddoway B, Kaeser GE, Segota I, Rivera R, Romanow WJ, Liu CS, Park C, Kennedy G, Long T, Chun J. Nature 2018;563(7733):639-645.

Submegabase Copy Number Variations Arise During Cerebral Cortical Neurogenesis as Revealed By Single-Cell Whole-Genome Sequencing

Rohrback S, April C, Kaper F, Rivera RR, Liu CS, Siddoway B, Chun J. Proc Natl Acad Sci USA 2018;115(42):10804-10809.

Integrative Single-Cell Analysis of Transcriptional and Epigenetic States in the Human Adult Brain

Lake BB, Chen S, Sos BC, Fan J, Kaeser GE, Yung YC, Duong TE, Gao D, Chun J, Kharchenko PV, Zhang K. Nat Biotechnol 2018;36(1):70-80.

Type: Article, Year: 2018, Publications, Highlighted ArticlesScienceSitesJune 7, 2021SnRNA-seq

A Functionally Defined in Vivo Astrocyte Population Identified By c-Fos Activation in a Mouse Model of Multiple Sclerosis Modulated by S1P Signaling: Immediate Early Astrocytes (ieAstrocytes)

Groves A, Kihara Y, Jonnalagadda D, Rivera R, Kennedy G, Mayford M, Chun J. eNeuro 2018; 5(5).

Genomic Mosaicism in the Developing and Adult Brain

Rohrback S, Siddoway B, Liu CS, Chun J. Dev Neurobiol 2018;78:1026-1048.

A Comparative Strategy for Single-Nucleus and Single-Cell Transcriptomes Confirms Accuracy in Predicted Cell-Type Expression From Nuclear RNA

Lake BB, Codeluppi S, Yung YC, Chun J, Kharchenko PV, Linnarsson S, Zhang K. Sci Rep 2017;7(1):6031.

Type: Article, Year: 2017, Publications, Highlighted ArticlesScienceSitesJune 7, 2021SnRNA-seq

Neuronal Subtypes and Diversity Revealed By Single-Nucleus RNA Sequencing of the Human Brain

Lake BB, Ai R, Kaeser GE, Salathia NS, Yung YC, Liu R, Wildberg A, Gao D, Fung H-L, Chen S, Vijayaraghavan R, Wong J, Chen C, Sheng X, Kaper F, Shen R, Ronaghi M, Fan J-B, *Wang W, *Chun J, *Zhang K. Science 2016;352(6293):1586-1590.
*co-senior authors

Type: Article, Year: 2016, Publications, Highlighted ArticlesScienceSitesJune 7, 2021SnRNA-seq

Characterizing Transcriptional Heterogeneity Through Pathway and Gene Set Overdispersion Analysis

Fan J, Salathia N, Liu R, Kaeser GE, Yung YC, Herman JL, Kaper F, Fan JB, Zhang K, Chun J, Kharchenko PV. Nat Methods 2016;13(3):241-244.

Type: Article, Year: 2016, Publications, Highlighted ArticlesScienceSitesJune 7, 2021SnRNA-seq

Crystal Structure of Antagonist Bound Human Lysophosphatidic Acid Receptor 1

Chrencik JE, Roth CB, Terakado M, Kurata H, Omi R, Kihara Y, Warshaviak D, Nakade S, Asmar-Rovira G, Mileni M, Mizuno H, Griffith MT, Rodgers C, Han GW, Velasquez J, Chun J*, Stevens RC*, Hanson MA*. Cell 2015;161:1633-1643.
*co-senior authors.

Type: Article, Year: 2015, Publications, Highlighted ArticlesScienceSitesJune 7, 2021LPA

LPA Signaling Initiates Schizophrenia-Like Brain and Behavioral Changes in a Mouse Model of Prenatal Brain Hemorrhage

Mirendil H, Thomas EA, De Loera C, Okada K, Inomata Y, Chun J. Transl Psychiatry 2015;5:e541. doi:10.1038/tp.2015.33.

Type: Article, Year: 2015, Publications, Highlighted ArticlesScienceSitesJune 4, 2021LPA, Hydrocephalus

Genomic Mosaicism With Increased Amyloid Precursor Protein (APP) Copy Number in Single Neurons From Sporadic Alzheimer’s Disease Brains

Bushman DM, Kaeser GE, Siddoway B, Westra JW, Rivera RR, Rehen SK, Yung YC, Chun J. eLife 2015;4:e05116. doi:10.7554/eLife.05116

Lysophosphatidic Acid Signaling in the Nervous System

Yung YC, Stoddard NC, Mirendil H, Chun J. Neuron 2015;85(4):669-682. doi:10.1016/j.neuron.2015.01.009.

Type: Review, Year: 2015, Publications, Highlighted ArticlesScienceSitesJune 4, 2021LPA

LPA Receptor Signaling: Pharmacology, Physiology, and Pathophysiology

Yung YC, Stoddard NC, Chun J. J Lipid Res 2014;55(7):1192-1214.

Type: Review, Year: 2014, Publications, Highlighted ArticlesScienceSitesJune 4, 2021LPA

Fingolimod: Direct CNS Effects of Sphingosine 1- Phosphate (S1P) Receptor Modulation and Implications in Multiple Sclerosis Therapy

Groves A, Kihara Y, Chun J. J Neurol Sci 2013;328(1-2):9-18.

Aneuploid Cells Are Differentially Susceptible to Caspase-Mediated Death During Embryonic Cerebral Cortical Development

Peterson SE, Yang AH, Bushman DM, Westra JW, Yung YC, Barral S, Mutoh T, Rehen SK, Chun J. J Neurosci 2012;32(46):16213-16222.

Targeted Deletion of LPA5 Identifies Novel Roles for Lysophosphatidic Acid Signaling in Development of Neuropathic Pain

Lin ME, Rivera RR, Chun J. J Biol Chem 2012;287(21):17608-17617.

Lysophosphatidic Acid Signaling May Initiate Fetal Hydrocephalus

Yung YC, Mutoh T, Lin ME, Noguchi K, Rivera RR, Choi JW, Kingsbury MA, Chun J. Sci Transl Med 2011;3:99ra87.

Type: Article, Year: 2011, Publications, Highlighted ArticlesScienceSitesJune 4, 2021LPA, Hydrocephalus

FTY720 (Fingolimod) Efficacy in an Animal Model of Multiple Sclerosis Requires Astrocyte Sphingosine 1-Phosphate Receptor (S1P1) Modulation

Choi JW, Gardell SE, Herr DR, Rivera R, Lee CW, Noguchi K, Teo ST, Yung YC, Lu M, Kennedy G, Chun J. Proc Natl Acad Sci USA 2011;108(2):751-756.

Neuronal DNA Content Variation (DCV) With Regional and Individual Differences in the Human Brain

Westra JW, Rivera RR, Bushman DM, Yung YC, Peterson SE, Barral S, Chun J. J Comp Neuro 2010;518(19):3981-4000.

LPA Receptors: Subtypes and Biological Actions

Choi JW, Herr DR, Noguchi K, Yung YC, Lee CW, Mutoh T, Lin M-E, Teo ST, Park KE, Mosley AN, Chun J. Ann Rev Pharmacol Toxicol 2010;50:157–186.

Type: Review, Year: 2010, Publications, Highlighted ArticlesScienceSitesJune 3, 2021LPA

Aneuploidy in the Normal and Diseased Brain

Kingsbury MA, Yung YC, Peterson SE, Westra JW, Chun J. Cell Mol Life Sci 2006;63:2626-2641.

LPA3-Mediated Lysophosphatidic Acid Signalling in Embryo Implantation and Spacing

Ye X, Hama K, Contos JJ, Anliker B, Inoue A, Skinner MK, Suzuki H, Amano T, Arai H, Aoki J, Chun J. Nature 2005;435:104-108.

Type: Article, Year: 2005, Publications, Highlighted ArticlesScienceSitesJune 3, 2021LPA

Constitutional Aneuploidy in the Normal Human Brain

Rehen SK, Yung YC, McCreight MP, Yang AH, Almeida BSV, Kingsbury MA, Cabral KMS, Kaushal D, McConnell MJ, Anliker B, Fontanoz M, Chun J. J Neurosci 2005;25:2176-2180.