Genomic Mosaicism — Publications

McDonald WS, Miyamoto K, Rivera R, Kennedy G, Almeida BSV , Kingsbury MA, and Chun J. Molecular Brain 2020;13(1):169. doi: 10.1186/s13041-020-00709-y.

Reply: Evidence That APP Gene Copy Number Changes Reflect Recombinant Vector Contamination

Lee MH, Liu CS, Zhu Y, Kaeser GE, Rivera R, Romanow WJ, Kihara Y, Chun J. Nature 2020;584(7821):E29-E33. doi:10.1038/s41586-020-2523-2.

Brain Cell Somatic Gene Recombination and Its Phylogenetic Foundations

Kaeser GE, Chun J. J Biol Chem 2020;295(36):12786-12795.

Mosaic Somatic Gene Recombination as a Potentially Unifying Hypothesis for Alzheimer’s Disease

Kaeser GE, Chun J. Front Genet 2020;11:390. doi: 10.3389/fgene.2020.00390.

The Gene Conundrum in Alzheimer’s Disease

Chun J. Cerebrum 2019.

Mosaic APP Gene Recombination in Alzheimer’s Disease - What’s Next?

Lee MH, Chun J. J Exp Neurosci 2019;13. doi:10.1177/1179069519849669.

Somatic APP Gene Recombination in Alzheimer’s Disease and Normal Neurons

Lee MH, Siddoway B, Kaeser GE, Segota I, Rivera R, Romanow WJ, Liu CS, Park C, Kennedy G, Long T, Chun J. Nature 2018;563(7733):639-645.

Submegabase Copy Number Variations Arise During Cerebral Cortical Neurogenesis as Revealed By Single-Cell Whole-Genome Sequencing

Rohrback S, April C, Kaper F, Rivera RR, Liu CS, Siddoway B, Chun J. Proc Natl Acad Sci USA 2018;115(42):10804-10809.

Genomic Mosaicism in the Developing and Adult Brain

Rohrback S, Siddoway B, Liu CS, Chun J. Dev Neurobiol 2018;78:1026-1048.

Genomic Mosaicism With Increased Amyloid Precursor Protein (APP) Copy Number in Single Neurons From Sporadic Alzheimer’s Disease Brains

Bushman DM, Kaeser GE, Siddoway B, Westra JW, Rivera RR, Rehen SK, Yung YC, Chun J. eLife 2015;4:e05116. doi:10.7554/eLife.05116

Massively Parallel Polymerase Cloning and Genome Sequencing of Single Cells Using Nanoliter Microwells

Gole J, Gore A, Richards A, Chiu YJ, Fung HL, Bushman D, Chiang HI, Chun J, Lo YH, Zhang K. Nature Biotechnol 2013;31(12):1126-32.

Type: Article, Year: 2013, PublicationsScienceSitesJune 4, 2021Genomic Mosaicism

The Genomically Mosaic Brain: Aneuploidy and More in Neural Diversity and Disease

Bushman DM, Chun J. Semin Cell Dev Biol 2013;24(4):357-369.

Type: Review, Year: 2013, PublicationsScienceSitesJune 4, 2021Genomic Mosaicism

Aneuploid Cells Are Differentially Susceptible to Caspase-Mediated Death During Embryonic Cerebral Cortical Development

Peterson SE, Yang AH, Bushman DM, Westra JW, Yung YC, Barral S, Mutoh T, Rehen SK, Chun J. J Neurosci 2012;32(46):16213-16222.

Normal Human Pluripotent Stem Cell Lines Exhibit Pervasive Mosaic Aneuploidy

Peterson SE, Westra JW, Rehen SK, Young H, Bushman DM, Paczkowski CM, Yung YC, Lynch CL, Tran HT, Nickey KS, Wang YC, Laurent LC, Loring JF, Carpenter MK, Chun J. PLoS ONE 2011;6(8):e23018.

Type: Article, Year: 2011, PublicationsScienceSitesJune 4, 2021Genomic Mosaicism

A Reply to Lourov I. et al

Chun J, Westra JW, Bushman D. Neurodegen Dis 2011;8(1- 2):38-40.

Type: Article, Year: 2011, PublicationsScienceSitesJune 4, 2021Genomic Mosaicism

Neuronal DNA Content Variation (DCV) With Regional and Individual Differences in the Human Brain

Westra JW, Rivera RR, Bushman DM, Yung YC, Peterson SE, Barral S, Chun J. J Comp Neuro 2010;518(19):3981-4000.

A Reevaluation of Tetraploidy in the Alzheimer’s Disease Brain

Westra JW, Barral S, Chun J. Neurodegen Dis 2009;6(5-6):221-229.

Type: Article, Year: 2009, PublicationsScienceSitesJune 3, 2021Genomic Mosaicism

Chromosomal Mosaicism in Neural Stem Cells

Peterson SE, Westra JW, Paczkowski CM, Chun J. Methods Mol Biol 2008;438:197-204.

Aneuploid Mosaicism in the Developing and Adult Cerebellar Cortex

Westra JW, Peterson SE, Yung YC, Mutoh T, Barral S, Chun J. J Comp Neurol 2008 507(6):1944-1951.

Numerical Chromosome Variation and Mitotic Segregation Defects in the Adult Brain of Teleost Fish

Rajendran RS, Zupanc MM, Losche A, Westra J, Chun J, Zupanc GKH. Dev Neurobiol 2007;67(10):1334-1347.

Type: Article, Year: 2007, PublicationsScienceSitesJune 3, 2021Genomic Mosaicism

Aneuploidy in the Normal and Diseased Brain

Kingsbury MA, Yung YC, Peterson SE, Westra JW, Chun J. Cell Mol Life Sci 2006;63:2626-2641.

Aneuploid Neurons Are Functionally Active and Integrated Into Brain Circuitry

Kingsbury MA, Friedman B, McConnell MJ, Rehen SK, Yang AH, Kaushal D, Chun J. Proc Natl Acad Sci USA 2005;102:6143-6147.

Type: Article, Year: 2005, PublicationsScienceSitesJune 3, 2021Genomic Mosaicism

Constitutional Aneuploidy in the Normal Human Brain

Rehen SK, Yung YC, McCreight MP, Yang AH, Almeida BSV, Kingsbury MA, Cabral KMS, Kaushal D, McConnell MJ, Anliker B, Fontanoz M, Chun J. J Neurosci 2005;25:2176-2180.

Failed Clearance of Aneuploid Embryonic Neural Progenitor Cells Leads to Excess Aneuploidy in Atm-Deficient But Not the Trp53-Deficient Adult Cerebral Cortex

McConnell MJ, Kaushal D, Yang AH, Kingsbury MA, Rehen SK, Treuner K, Helton R, Annas EG, Chun J, Barlow C. J Neurosci 2004;24:8090-8096.

Type: Article, Year: 2004, PublicationsScienceSitesJune 3, 2021Genomic Mosaicism

Chromosome Segregation Defects Contribute to Aneuploidy in Normal Neural Progenitor Cells

Yang AH, Kaushal D, Rehen SK, Kriedt K, Kingsbury MA, McConnell MJ, Chun J. J Neurosci 2003;23:10454-10462.

Type: Article, Year: 2003, PublicationsScienceSitesJune 3, 2021Genomic Mosaicism

Alteration of Gene Expression By Chromosome Loss in the Postnatal Mouse Brain

Kaushal D, Contos JJA, Treuner K, Yang AH, Kingsbury MA, Rehen SK, McConnell MJ, Okabe M, Barlow C, Chun J. J Neurosci 2003;23:5599-5606.

Type: Article, Year: 2003, PublicationsScienceSitesJune 3, 2021Genomic Mosaicism

Chromosomal Variation in Neurons of the Developing and Adult Mammalian Nervous System

Rehen SK, McConnell MJ, Kaushal D, Kingsbury MA, Yang AH, Chun J. Proc Natl Acad Sci USA, 2001;98:13361-13366.

Developmental Neurobiology: A Genetic Cheshire Cat?

Chun J. Curr Biol 1999;9:651-4.

Apoptotic DNA Fragmentation Is Detected By a Semi-Quantitative Ligation-Mediated PCR of Blunt DNA Ends

Staley K, Blaschke AJ, Chun J. Cell Death and Differen 1997;4:66-75.

Type: Article, Year: 1997, PublicationsScienceSitesMay 28, 2021Methods, Genomic Mosaicism

Widespread Programmed Cell Death in Proliferative and Postmitotic Regions of the Fetal Cerebral Cortex

Blaschke AJ, Staley K, Chun J. Development 1996;122:1165-1174 (see comment in Neuron 1996;16:693).

The Recombination Activating Gene-1 (RAG-1) Transcript Is Present in the Murine Central Nervous System

Chun JJM, Schatz DG, Oettinger MA, Jaenisch R, Baltimore D. Cell 1991;64:189-200.